Deep Dives
Cholesterol, lipids, and cardiovascular risk.
APOE4 does not only affect the brain. It shapes how your body handles cholesterol, which makes cardiovascular health the most concrete, trackable, and treatable lever carriers have.
Standard panels report LDL-C, but ApoB counts the particles that drive artery disease. Why the distinction matters for APOE4 carriers, and how to get and read it.
High blood pressure is one of the best-established modifiable risk factors for dementia. Why it matters so much for APOE4 carriers, the numbers, and how to keep it in range.
Blood sugar control is not only a diabetes issue. It is increasingly tied to brain health. What insulin resistance has to do with cognitive risk, the markers to watch, and what helps.
LDL, HDL, triglycerides, non-HDL, ApoB, Lp(a): a friendly walkthrough of every number on your cholesterol report and which ones actually deserve your attention.
Statins are among the most-studied and most-debated drugs in medicine. What they do, the cognitive worry in context, and the genotype-specific evidence for APOE4 carriers.
Lipoprotein(a) is a common, largely genetic driver of heart and stroke risk that standard panels miss. Why every APOE4 carrier should measure it once, and what to do if it’s high.
An ApoA-I Milano variant cut vascular amyloid in Alzheimer's mice. What HDL apolipoproteins mean for cerebral amyloid angiopathy in APOE4 carriers.
Finnish men who used the sauna most often had about two-thirds less dementia. The signal is real and appealing, but it is observational. Here is what it can and cannot tell an APOE4 carrier.
Low testosterone tracks with modestly higher dementia risk in men, but randomized trials of replacing it found no cognitive benefit. The men's counterpart to the estrogen question, graded honestly.