Sleep, the glymphatic system, and APOE4
Why sleep keeps coming up in Alzheimer’s research, what the glymphatic system is, the two-way street between sleep and amyloid, and practical sleep priorities for carriers.
Updated June 16, 2026 8 min
Deep Dives
Sleep & Stress
Recovery, glymphatics, and resilience.
All topics
Sleep & Stress Sleep & Stress Sleep & Stress Sleep & Stress Sleep & Stress Sleep & Stress
Sleep apnea and cognitive risk: the underdiagnosed lever
Obstructive sleep apnea is common, often silent, harmful to the brain and heart, and very treatable. Why it deserves attention from APOE4 carriers, and how to get evaluated.
Updated June 16, 2026 8 min
Stress, cortisol, and the brain
Chronic stress touches blood pressure, sleep, mood, and behavior in ways that matter for brain health. The mechanism, and practical, evidence-aligned ways to manage it.
Updated June 16, 2026 8 min
Building a brain-protective sleep routine
You can’t hack your way to good sleep, but you can engineer the conditions for it. A practical, no-nonsense routine for carriers who take the brain seriously.
Updated June 16, 2026 8 min
Naps, melatonin, and sleep aids: what’s reasonable?
Should you nap? Is melatonin safe nightly? What about pharmacy sleep aids and the anticholinergic concern? A practical, evidence-aware guide for carriers.
Updated June 16, 2026 8 min
Shift work, jet lag, and the body clock
Your circadian rhythm governs sleep, metabolism, and brain waste-clearance. What happens when shift work or travel disrupts it, and how carriers can protect the clock.
Updated June 16, 2026 8 min